論文リスト

英文原著論文

1. Iwabuchi,K.*, Matsui,T., Hashimoto,M., Matsumoto,Y., Kurihara,T. and Date,T.　 Characterization of a cancer cell-line that expresses a splicing variant form of 53BP1: separation of checkpoint and repair functions in 53BP1.　 Biochem.Biophys.Res.Commun., 379, 509-513 (2008)
2. Tomita,M.*, Morohoshi,F., Matsumoto,Y., Ohtsuka,K., Nomura,T. and Sakai,K.　 Roles of DNA double-strand break repair genes in sustaining cell proliferation under low dose-rate irradiation.　 J. Radiat. Res., 49, 557-564 (2008).
3. Enomoto, A.*, Kido, N., Ito, M., Morita, A., Matsumoto, Y., Takamatsu, N., Hosoi, Y. and Miyagawa, K.　 Negative regulation of MEKK1/2 signaling by Serine-Threonine kinase 38 (STK38).　 Oncogene, 27, 1930-1938 (2008).
4. Someya, M., Sakata, K.*, Matsumoto, Y., Satoh, M., Narimatsu, H. and Hareyama, M.　 Immunohistochemical analysis of Ku70/86 expression of breast cancer tissues.　 Oncology Reports, 18, 1483-1487 (2007).
5. Sasano, N., Enomoto, A., Hosoi, Y., Katsumura, Y., Matsumoto, Y., Shiraishi, K., Miyagawa, K., Igaki, H. and Nakagawa, K.*　 Free radical scavenger edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells.　 J. Radiat. Res., 48, 495-504 (2007).
6. Someya, M., Sakata, K.*, Matsumoto, Y., Tauchi, H., Narimatsu, H. and Hareyama, M.　 Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients.　 Oncology Reports, 18, 873-878 (2007).
7. Sakata, K.*, Yamamoto, H., Matsumoto, Y., Someya, M. and Hareyama, M.　 cDNA analysis of gene expression associated with DNA-dependent protein kinase activity.　 Int. J. Oncol., 30, 413-420 (2007).
8. Hosoi, Y.*, Kapp, L. N., Murnane, J. P., Matsumoto, Y., Enomoto, A., Ono, T. and Miyagawa, K.　 Suppression of anchorage-independent growth by expression of ataxia-telangiectasia group D complementing gene, ATDC.　 Biochem. Biophys. Res. Commun., 348, 728-734 (2006).
9. Someya, M., Sakata, K.*, Tauchi, H., Matsumoto, Y., Nakamura, A., Komatsu, K. and Hareyama, M.　 Association of ionizing radiation-induced foci of NBS1 with chromosomal instability and breast cancer susceptibility.　 Radiat. Res., 166, 575-582(2006).
10. Someya, M., Sakata, K.* Matsumoto, Y., Yamamoto, H., Monobe, M., Ikeda, H., Ando, K., Hosoi, Y., Suzuki, N. and Hareyama, M.　 The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer.　 Carcinogenesis, 27, 117-122 (2006).
11. Li, Z., Hosoi, Y.*, Cai, K., Tanno, Y., Matsumoto, Y., Enomoto, A. Morita, A. Nakagawa, K. and Miyagawa, K.　 Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation.　 Biochem. Biophys. Res. Commun., 342, 363-368 (2006)
12. Tonotsuka, N., Hosoi, Y.*, Miyazaki, S., Miyata, G., Sugawara, K., Mori, T., Ouchi, N., Satomi, S., Matsumoto, Y., Nakagawa, K., Miyagawa, K. and Ono, T.　 Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium.　 Int. J. Mol. Med., 18, 441-447 (2006).
13. Yuita, H., Tsuiji, M., Tajika, Y., Matsumoto, Y., Hirano, K., Suzuki, N. and Irimura, T.*　 Retardation of removal of radiation-induced apoptotic cells in developing neural tubes in macrophage galactose-type C-type lectin-1-deficient mouse embryos.　 Glycobiology, 15, 1368-1375 (2005).
14. Komuro, Y.*, Watanabe, T., Hosoi, Y., Matsumoto, Y., Nakagawa, K., Suzuki, N. and Nagawa, H.　 Prognostic significance of Ku70 protein expression in patients with advanced colorectal cancer.　 Hepato-Gastroenterology, 52, 995-998 (2005).
15. Morita, A.*, Zhu, J., Suzuki, N., Enomoto, A., Matsumoto, Y., Tomita, M., Suzuki, T., Ohtomo, K. and Hosoi, Y.　 Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53.　 Cell Death Diff. 13, 499-511 (2005).
16. Komiyama, S., Taniguchi, S., Matsumoto, Y.*, Tsunoda, E., Ohto, T., Suzuki, Y., Yin, H.-L., Tomita, M., Enomoto, A., Morita, A., Suzuki, T., Ohtomo, K., Hosoi, Y. and Suzuki N. Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53.　 Biochem. Biophys. Res. Commun., 323, 816-822 (2004).
17. Yin, H.-L., Suzuki, Y., Matsumoto, Y.*, Tomita, M., Furusawa, Y., Enomoto, A., Morita, A., Aoki, M., Yatagai, F., Suzuki, T., Hosoi, Y., Ohtomo, K. and Suzuki, N. Radiosensitization by hyperthermia in chicken B lymphocyte cell line DT40 and its derivatives lacking non-homologous end-joining and/or homologous recombination pathways of DNA double-strand break repair.　 Radiat. Res., 162, 433-441 (2004).
18. Hosoi, Y.*, Matsumoto, Y., Enomoto, A., Morita, A., Green, J., Nakagawa, K., Naruse, K. and Suzuki, N.　 Suramin Sensitizes Cells to Ionizing Radiation by Inactivating DNA-Dependent Protein Kinase.　 Radiat. Res. 162, 308-314 (2004).
19. Hosoi, Y.*, Watanabe, T., Nakagawa, K., Matsumoto, Y., Enomoto, A., Morita, A., Nagawa, H. and Suzuki, N.　 Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer.　 Int. J. Oncol. 25, 461-468 (2004).
20. Umeda, N., Matsumoto, Y.*, Yin, H.-L., Tomita, M., Enomoto, A., Morita, A., Mizukoshi, T., Sakai, K., Hosoi, Y. and Suzuki, N.　 Difference in the heat sensitivity of DNA-dependent protein kinase activity among mouse, hamster and human cells.　 Int. J. Radiat. Biol., 79, 671-680 (2003).
21. Enomoto, A., Suzuki, N.*, Kang, Y., Hirano, K., Matsumoto, Y., Zhu, J., Morita, A., Hosoi, Y., Sakai, K. and Koyama, H.　 Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukemia cell line MOLT-4.　 Int. J. Radiat. Biol., 79, 589-600 (2003).
22. Komuro, Y.*, Watanabe, T., Hosoi, Y., Matsumoto, Y., Nakagawa, K., Saito, S., Ishihara, S., Kazama, S., Tsuno, N., Kitayama, J., Suzuki, N., Tsurita, G., Muto, T. and Nagawa, H.　 Prediction of tumor radiosensitivity in rectal carcinoma based on p53 and Ku70 expression.　 J. Exp. Clin. Cancer Res., 22, 223-228 (2003).
23. Tomita, M., Suzuki, N.*, Matsumoto, Y., Enomoto, A., Yin, H.-L., Hosoi, Y., Hirano, K. and Sakai, K.　 Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/SAPK pathway.　 Radiat. Res., 160, 467-477 (2003).
24. Enomoto, A.*, Suzuki, N., Morita, A., Ito, M., Liu, C. Q., Matsumoto, Y., Yoshioka, K., Shiba, T. and Hosoi, Y.　 Caspase-mediated cleavage of JNK during stress-induced apoptosis.　 Biochem. Biophys. Res. Commun., 306, 837-842 (2003).
25. Hosoi, Y.*, Matsumoto, Y., Tomita, M., Enomoto, A., Morita, A., Sakai, K. Umeda, N., Zhao, H.-J., Nakagawa, K., Ono, T. and Suzuki, N.　 Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity.　 Brit. J. Cancer, 86, 1143-1149 (2002).
26. Komuro, Y.*, Watanabe, T., Hosoi, Y., Matsumoto, Y., Nakagawa, K., Tsuno, N., Kazama, S., Kitayama, J., Suzuki, N. and Nagawa, H.　 The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma.　 Cancer 95, 1195-1205 (2002).
27. Yoshida, M., Hosoi, Y.*, Miyachi, H., Ishii, N., Matsumoto, Y., Enomoto, A., Nakagawa, K., Yamada, S., Suzuki, N. and Ono, T.　 Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells.　 Int. J. Radiat. Biol. 78, 503-512 (2002).
28. Mori, N.*, Matsumoto, Y., Okumoto, M.,Suzuki, N. and Yamate, J.　 Variations in Prkdc encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and susceptibility to radiation-induced apoptosis and lymphomagenesis.　 Oncogene, 20, 3609-3619 (2001).
29. Sakata, K.*, Matsumoto, Y., Satoh, M., Oouchi, A., Nagakura, H., Koito, K., Hosoi, Y., Hareyama, M., and Suzuki, N.　 Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas.　 Radiat. Med., 19, 93-97 (2001).
30. Sakata, K.*, Matsumoto, Y., Tauchi, H., Satoh, M., Oouchi, A., Nagakura, H., Koito, K., Hosoi, Y., Suzuki, N., Komatsu, K., and Hareyama, M.　 Expression of genes involved in repair of DNA double-strand breaks in normal and tumor tissues.　 Int. J. Radiat. Oncol. Biol. Phys., 49, 161-167 (2001).
31. Enomoto, A., Suzuki, N.*, Liu, C., Kang, Y., Zhu, J., Serizawa, S., Matsumoto, Y., Morita, A., Ito, M., and Hosoi, Y.　 Involvement of c-Jun NH2-terminal kinase 1 in heat-induced apoptotic cell death of human monoblastic leukemia U937 cells.　 Int. J. Radiat. Biol., 867-874 (2001).
32. Matsumoto, Y.*, Suzuki, N., Namba, N., Umeda, N., Ma, X.-J., Morita, A., Tomita, M., Enomoto, A., Serizawa, S., Hirano, K., Sakai, K., Yasuda, H., and Hosoi, Y.　 Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation.　 FEBS Lett. 478, 67-71 (2000).
33. Hosoi, Y.*, Miyachi, H., Matsumoto, Y., Enomoto, A., Nakagawa, K., Suzuki, N. and Ono, T. 　Induction of interleukin-1beta and interleukin-6 mRNA by low doses of ionizing radiation in macrophages. Int. J. Cancer, 96, 270-276 (2001).
34. Tomita, M., Suzuki, N.*, Matsumoto, Y., Hirano, K., Umeda, N., and Sakai, K.　 Sensitization by wortmannin of heat- or X-ray induced cell death in cultured chinese hamster V79 cells.　 J. Radiat. Res. 41, 93-102 (2000).
35. Enomoto, A., Suzuki, N.*, Hirano, K., Matsumoto, Y., Morita, A., Sakai, K., and Koyama, H.　 Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4.　 Cancer Lett. 155, 137-144 (2000).
36. Morita, A., Suzuki, N.*, Matsumoto, Y., Hirano, K., Enomoto, A., Zhu, J., and Sakai, K.　 p41 as a possible marker for cell death is generated by caspase cleavage of p42/SETb in irradiated MOLT-4 cells.　 Biochem. Biophys. Res. Commun., 278, 627-632 (2000).
37. Matsumoto, Y., Umeda, N., Suzuki, N.*, Sakai, K., and Hirano, K.　 A gel-electrophoretic analysis for improved sensitivity and specificity of DNA-dependent protein kinase activity.　 J. Radiat. Res. 40, 183-196 (1999).
38. Hosoi, Y.*, Miyachi, H., Matsumoto, Y., Ikehata, H., Komura, J., Ishii, K., Zhao, H.-J., Yoshida, M., Takai, Y., Yamada, S., Suzuki, N., and Ono, T.　 A PI-3 kinase inhibitor, wortmannin, induces radioresistant DNA synthesis, and sensitizes cells to bleomycin and ionizing radiation.　 Int. J. Cancer 78, 642-647 (1998).
39. Matsumoto, Y., Suzuki, N.*, Sakai, K., Morimatsu, A., Hirano, K., and Murofushi H.　 A possible mechanism for hyperthermic radiosensitization mediated through hyperthermic lability of Ku subunits in DNA-dependent protein kinase.　 Biochem. Biophys. Res. Commun. 234, 568-572 (1997).
40. Morimatsu, A., Suzuki, N.*, Hirano, K., Matsumoto, Y., and Sakai, K.　 Identification and characterization of a protein found after X-irradiation in human T cell leukemia.　 J. Radiat. Res. 37, 1 11 (1996).

英文総説等

1. Sakata, K.*, Someya, M., Matsumoto, Y., and Hareyama, M.　 Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity.　 Radiat. Med. 25, 433-438 (2007).

和文総説・解説等

1. 松本義久　「Not at the end of DNA double-strand break repair：新たに発見されたDNA二重鎖切断修復の重要分子XLF/Cernunnos」　放射線生物研究　41, 325-331 (2006).
2. 松本義久　「DNA切断センサーDNA-PKの性質と機能に関する研究－その成果は癌診断・治療にいかに生かせるか？」　癌と人　33, 31-32 (2006).
3. 松本義久　「第１回アジア若手放射線生物学研究者会合開催記」　放射線生物研究　40, 461-465 (2005).
4. 松本義久　「DNA二重鎖切断センサー：DNA依存性プロテインキナーゼ(DNA-PK)機能研究の現状と課題」　放射線生物研究　40, 82-108 (2005).
5. 松本義久、梅田典子、冨田雅典、細井義夫、鈴木紀夫　「DNA依存性プロテインキナーゼの性質と放射線感受性-DNA-PKの温熱不安定性と温熱の放射線増感効果について-」　癌の臨床　47, 3-7 (2001).
6. 松本義久　「イノシトールヘキサキスリン酸がDNA２重鎖切断の修復に関与する！？」　放射線生物研究　38, 70-73 (2001).
7. 松本義久　「DNA依存性プロテインキナーゼ(DNA-PK)とその放射線応答における意義-The end is the beginning of the story.-」　放射線生物研究　31, 1-27 (1996).

著書等

1. 松本義久　「放射線によるＤＮＡ損傷の修復」　大西武雄監修「放射線医科学」, 18-21, 学会出版センター(2007).

工業所有権

1. 坂田耕一、染谷正則、松本義久　「癌の診断方法、及び癌の罹病性の判定方法」　出願人：北海道ティー・エル・オー株式会社、出願番号：PCTF157、出願日：2003年6月4日

招待講演・特別講演等

1. Lecture at University of Rajasthan, Department of Zoology “DNA-dependent Protein Kinase: The Sensor of DNA double-strand Break and Critical Determinant of Radiosensitivity” 25 November 2006, University of Rajasthan (Jaipur, India).
2. International Conference on Radiation Biology "Missing link in the mechanism of DNA double-strand break repair through non-homologouse end-joining pathway" 20 November 2006, Banaras Hindu University (Varanasi, India).
3. ACTREC Lecture "DNA-PK: The Sensor of DNA Double-Strand Breaks Bringing Us Many Hopes in Cancer Therapy and Diagnosis" 17 November 2006, The Advanced Centre for Training Education & Research in Cancer, The Tata Memorial Centre (Mumbai, India).
4. 東北大学加齢医学研究所研究員会セミナー　「DNA切断センサーDNA-PKの性質と機能：新しいサイエンス・フロンティアとがん診断・治療への応用の可能性」　平成18年2月22日、東北大学(仙台市).
5. 広島大学21世紀COEプログラム第13回セミナー　「DNA切断センサーDNA-PKの性質と機能：新しいサイエンス・フロンティアとがん診断・治療への応用の可能性」　平成17年9月1日、広島大学(広島市).
6. 理研セミナー　「DNA切断センサーDNA-PKの性質と機能：新しいサイエンス・フロンティアとがん診断・治療への応用の可能性」平成17年１月７日、理化学研究所（和光市）