研究業績

【英文原著論文】

(全て英文Peer-Review誌、*はCorresponding author、メンバーに下線)


1.Fukuchi M, Wanotayan R, Liu S, Imamichi S, Sharma MK, Matsumoto Y*. Lysine 271 but not lysine 210 of XRCC4 is required for the nuclear localization of XRCC4 and DNA ligase IV. Biochem. Biophys. Res. Commun., 461, 687-694 (2015). doi:10.1016/j.bbrc.2015.04.093

2.Wanotayan R, Fukuchi M, Imamichi S, Sharma MK, Matsumoto Y*. Asparagine 326 in the extremely C-terminal region of XRCC4 is essential for the cell survival after irradiation. Biochem. Biophys. Res. Commun., 457, 526-531 (2015). doi:10.1016/j.bbrc.2015.01.015. PMID: 25597996

3.Imamichi S, Sharma MK, Kamdar RP, Fukuchi M, Matsumoto Y*. Ionizing radiation-induced XRCC4 phosphorylation is mediated through ATM in addition to DNA-PK. Proceedings of Japan Academy Series B, 90, 365-372 (2014). http://doi.org/10.2183/pjab.90.365. PMID: 23994631

4.Liu S, Liu X, Kamdar RP, Wanotayan R, Sharma MK, Adachi N, Matsumoto Y*. C-terminal region of DNA ligase IV drives XRCC4/DNA ligase IV complex to chromatin. Biochem. Biophys. Res. Commun., 439, 173-178 (2013). DOI: http://dx.doi.org/10.1016/j.bbrc.2013.08.068. PMID: 23994631

5.Urushihara Y, Kobayashi J, Matsumoto Y, Komatsu K, Oda S, Mitani H*. DNA-PK inhibition causes a low level of H2AX phosphorylation and homologous recombination repair in Medaka (Oryzias latipes) cells. Biochem. Biophys. Res. Commun., 429, 131-136 (2012). DOI: 10.1016/j.bbrc.2012.10.128. PMID: 23142596

6.Ito Y, Ito T, Karasawa S, Enomoto T, Nashimoto A, Hase Y, Sakamoto S, Ito T, Mimori T, Matsumoto Y, Yamaguchi Y, Handa H*. Identification of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) as a novel target of Bisphenol A. PLoS ONE, 7(12), e50481 (2012). DOI: 10.1371/journal.pone.0050481. PMID: 23227178

7.Someya M, Sakata K*, Matsumoto Y, Tauchi H, Kai M, Hareyama M, Fukushima, M. Effects of depletion of dihidropyrimidine dehydrogenase on focus formation and RPA phosphorylation. J. Radiat. Res., 53, 250-256 (2012). PMID: 22510597

8.Miura K, Sakata K*, Someya M, Matsumoto Y, Matsumoto H, Takahashi A, Hareyama M. The combination of olaparib and camptothecin for effective radiosensitization. Radiat. Oncol., 96, 259-266 (2012). DOI: 10.1186/1748-717X-7-62. PMID: 22524618

9.Takagi M, Sakata K*, Someya M, Matsumoto Y, Tauchi H, Hareyama M. and Fukushima, M. The combination of hyperthermia or chemotherapy with gimeracil for effective radiosensitization. Strahlenther. Onkol., 188, 256-261 (2012). DOI: 10.1007/s00066-011-0043-6. PMID: 22322869

10.Hayashi J, Sakata K*, Someya M, Matsumoto Y, Satoh M, Kataya K, Hori M, Takagi M, Hareyama M. Analysis of Ku and XRCC4 expressions of hypopharyngeal cancer tissues and results treated with chemoradiotherapy. Oncol. Lett., 4, 151-155 (2012). DOI: 10.3892/ol.2012.674. PMID: 22807979

11.Sakata K*, Someya M, Matsumoto Y, Tauchi H, Kai M, Toyota M, Takagi M, Hareyama M, Fukushima M. Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination. Cancer Sci., 102, 1712-1716 (2011) DOI: 10.1111/j.1349-7006.2011.02004.x. PMID: 21668582

12.Tsuchimoto,T., Sakata,K.*, Someya,M., Yamamoto,H., Hirayama,R., Matsumoto,Y., Furusawa,Y. and Hareyama,M. Gene expression associated with DNA-dependent protein kinase activity under normoxia, hypoxia and reoxygenation. J.Radiat.Res., 52, 464-471 (2011) DOI: 10.1269/jrr.10137. PMID: 21905307

13.Someya,M., Sakata,K.*, Matsumoto,Y., Kamdar,R.P., Kai,M., Toyota,M. and Hareyama,M. The association of DNA-dependent protein kinase activity of peripheral blood lymphocytes with prognosis of cancer. Brit. J. Cancer, 104, 1724-1729 (2011) DOI: 10.1038/bjc.2011.158. PMID: 21559021

14.Takagi,M., Sakata,K.*, Someya,M., Tauchi,H., Iijima,K., Matsumoto,Y., Torigoe,T., Takahashi,A., Hareyama,M. and Fukushima,M. Gimeracil sensitizes cells to radiation via inhibition of homologous recombination. Radiother. Oncol., 96, 259-266 (2010) DOI: 10.1016/j.radonc.2010.05.020. PMID: 20584556

15.Kamdar,R.P. and Matsumoto,Y.* Radiation-induced XRCC4 Association with Chromatin DNA Analyzed by Biochemical Fractionation. J.Radiat.Res., 51, 303-313 (2010). PMID: 20448413

16.Sasano,N., Enomoto,A., Hosoi,Y., Katsumura,Y., Matsumoto,Y., Morita,A., Shiraishi,K., Miyagawa,K., Igaki,H. and Nakagawa,K.* Edaravone, a known free radical scavenger, enhances X-ray-induced apoptosis at low concentrations. Cancer Lett., 293, 521-527 (2010). doi: 10.1016/j.canlet.2009.12.020. PMID: 20092938

17.Morita,A.*, Yamamoto,S., Wang,B., Tanaka,K., Suzuki,N., Aoki,S., Ito,A., Nanao,T., Ohya,S., Yoshino,M., Zhu,J., Enomoto,A., Matsumoto,Y., Funatsu,O., Hosoi,Y. and Ikekita,M.* Sodium orthovanadate inhibits p53-mediated apoptosis. Cancer Res., 70, 257-265 (2010). DOI: 10.1158/0008-5472.CAN-08-3771. PMID: 20048077

18.Iwabuchi,K.*, Matsui,T., Hashimoto,M., Matsumoto,Y., Kurihara,T. and Date,T. Characterization of a cancer cell-line that expresses a splicing variant form of 53BP1: separation of checkpoint and repair functions in 53BP1. Biochem.Biophys.Res.Commun., 379, 509-513 (2008). DOI: 10.1016/j.bbrc.2008.09.022. PMID: 18804090

19.Tomita,M.*, Morohoshi,F., Matsumoto,Y., Ohtsuka,K., Nomura,T. and Sakai,K. Roles of DNA double-strand break repair genes in sustaining cell proliferation under low dose-rate irradiation. J. Radiat. Res., 49, 557-564 (2008). PMID: 18797158

20.Enomoto, A.*, Kido, N., Ito, M., Morita, A., Matsumoto, Y., Takamatsu, N., Hosoi, Y. and Miyagawa, K. Negative regulation of MEKK1/2 signaling by Serine-Threonine kinase 38 (STK38). Oncogene, 27, 1930-1938 (2008). PMID: 17906693

21.Someya, M., Sakata, K.*, Matsumoto, Y., Satoh, M., Narimatsu, H. and Hareyama, M. Immunohistochemical analysis of Ku70/86 expression of breast cancer tissues. Oncology Reports, 18, 1483-1487 (2007). PMID: 17982634

22.Sasano, N., Enomoto, A., Hosoi, Y., Katsumura, Y., Matsumoto, Y., Shiraishi, K., Miyagawa, K., Igaki, H. and Nakagawa, K.* Free radical scavenger edaravone suppresses X-ray-induced apoptosis through p53 inhibition in MOLT-4 cells. J. Radiat. Res., 48, 495-504 (2007). PMID: 17965547

23.Someya, M., Sakata, K.*, Matsumoto, Y., Tauchi, H., Narimatsu, H. and Hareyama, M. Association of DNA-PK activity and radiation-induced NBS1 foci formation in lymphocytes with clinical malignancy in breast cancer patients. Oncology Reports, 18, 873-878 (2007). PMID: 17786349

24.Sakata, K.*, Yamamoto, H., Matsumoto, Y., Someya, M. and Hareyama, M. cDNA analysis of gene expression associated with DNA-dependent protein kinase activity. Int. J. Oncol., 30, 413-420 (2007). PMID: 17203223

25.Hosoi, Y.*, Kapp, L. N., Murnane, J. P., Matsumoto, Y., Enomoto, A., Ono, T. and Miyagawa, K. Suppression of anchorage-independent growth by expression of ataxia-telangiectasia group D complementing gene, ATDC. Biochem. Biophys. Res. Commun., 348, 728-734 (2006). PMID: 16890201

26.Someya, M., Sakata, K.*, Tauchi, H., Matsumoto, Y., Nakamura, A., Komatsu, K. and Hareyama, M. Association of ionizing radiation-induced foci of NBS1 with chromosomal instability and breast cancer susceptibility. Radiat. Res., 166, 575-582(2006). PMID: 17007554

27.Someya, M., Sakata, K.* Matsumoto, Y., Yamamoto, H., Monobe, M., Ikeda, H., Ando, K., Hosoi, Y., Suzuki, N. and Hareyama, M. The association of DNA-dependent protein kinase activity with chromosomal instability and risk of cancer. Carcinogenesis, 27, 117-122 (2006). PMID: 16000400

28.Li, Z., Hosoi, Y.*, Cai, K., Tanno, Y., Matsumoto, Y., Enomoto, A. Morita, A. Nakagawa, K. and Miyagawa, K. Src tyrosine kinase inhibitor PP2 suppresses ERK1/2 activation and epidermal growth factor receptor transactivation by X-irradiation. Biochem. Biophys. Res. Commun., 342, 363-368 (2006). PMID: 16414009

29.Tonotsuka, N., Hosoi, Y.*, Miyazaki, S., Miyata, G., Sugawara, K., Mori, T., Ouchi, N., Satomi, S., Matsumoto, Y., Nakagawa, K., Miyagawa, K. and Ono, T. Heterogeneous expression of DNA-dependent protein kinase in esophageal cancer and normal epithelium. Int. J. Mol. Med., 18, 441-447 (2006). PMID: 16865228

30.Yuita, H., Tsuiji, M., Tajika, Y., Matsumoto, Y., Hirano, K., Suzuki, N. and Irimura, T.* Retardation of removal of radiation-induced apoptotic cells in developing neural tubes in macrophage galactose-type C-type lectin-1-deficient mouse embryos. Glycobiology, 15, 1368-1375 (2005). PMID: 16096344

31.Komuro, Y.*, Watanabe, T., Hosoi, Y., Matsumoto, Y., Nakagawa, K., Suzuki, N. and Nagawa, H. Prognostic significance of Ku70 protein expression in patients with advanced colorectal cancer. Hepato-Gastroenterology, 52, 995-998 (2005). PMID: 16001615

32.Morita, A.*, Zhu, J., Suzuki, N., Enomoto, A., Matsumoto, Y., Tomita, M., Suzuki, T., Ohtomo, K. and Hosoi, Y. Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53. Cell Death Diff. 13, 499-511 (2005). PMID: 16138109

33.Komiyama, S., Taniguchi, S., Matsumoto, Y.*, Tsunoda, E., Ohto, T., Suzuki, Y., Yin, H.-L., Tomita, M., Enomoto, A., Morita, A., Suzuki, T., Ohtomo, K., Hosoi, Y. and Suzuki N. Potentiality of DNA-dependent protein kinase to phosphorylate Ser46 of human p53. Biochem. Biophys. Res. Commun., 323, 816-822 (2004). PMID: 15381073

34.Yin, H.-L., Suzuki, Y., Matsumoto, Y.*, Tomita, M., Furusawa, Y., Enomoto, A., Morita, A., Aoki, M., Yatagai, F., Suzuki, T., Hosoi, Y., Ohtomo, K. and Suzuki, N. Radiosensitization by hyperthermia in chicken B lymphocyte cell line DT40 and its derivatives lacking non-homologous end-joining and/or homologous recombination pathways of DNA double-strand break repair. Radiat. Res., 162, 433-441 (2004). PMID: 15447039

35.Hosoi, Y.*, Matsumoto, Y., Enomoto, A., Morita, A., Green, J., Nakagawa, K., Naruse, K. and Suzuki, N. Suramin Sensitizes Cells to Ionizing Radiation by Inactivating DNA-Dependent Protein Kinase. Radiat. Res. 162, 308-314 (2004). PMID: 15378840

36.Hosoi, Y.*, Watanabe, T., Nakagawa, K., Matsumoto, Y., Enomoto, A., Morita, A., Nagawa, H. and Suzuki, N. Up-regulation of DNA-dependent protein kinase activity and Sp1 in colorectal cancer. Int. J. Oncol. 25, 461-468 (2004). PMID: 15254745

37.Umeda, N., Matsumoto, Y.*, Yin, H.-L., Tomita, M., Enomoto, A., Morita, A., Mizukoshi, T., Sakai, K., Hosoi, Y. and Suzuki, N. Difference in the heat sensitivity of DNA-dependent protein kinase activity among mouse, hamster and human cells. Int. J. Radiat. Biol., 79, 671-680 (2003). PMID: 14555350

38.Enomoto, A., Suzuki, N.*, Kang, Y., Hirano, K., Matsumoto, Y., Zhu, J., Morita, A., Hosoi, Y., Sakai, K. and Koyama, H. Decreased c-Myc expression and its involvement in X-ray-induced apoptotic cell death of human T-cell leukemia cell line MOLT-4. Int. J. Radiat. Biol., 79, 589-600 (2003). PMID: 14555342

39.Komuro, Y.*, Watanabe, T., Hosoi, Y., Matsumoto, Y., Nakagawa, K., Saito, S., Ishihara, S., Kazama, S., Tsuno, N., Kitayama, J., Suzuki, N., Tsurita, G., Muto, T. and Nagawa, H. Prediction of tumor radiosensitivity in rectal carcinoma based on p53 and Ku70 expression. J. Exp. Clin. Cancer Res., 22, 223-228 (2003). PMID: 12866572

40.Tomita, M., Suzuki, N.*, Matsumoto, Y., Enomoto, A., Yin, H.-L., Hosoi, Y., Hirano, K. and Sakai, K. Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/SAPK pathway. Radiat. Res., 160, 467-477 (2003). PMID: 12968928

41.Enomoto, A.*, Suzuki, N., Morita, A., Ito, M., Liu, C. Q., Matsumoto, Y., Yoshioka, K., Shiba, T. and Hosoi, Y. Caspase-mediated cleavage of JNK during stress-induced apoptosis. Biochem. Biophys. Res. Commun., 306, 837-842 (2003). PMID: 12821118

42.Hosoi, Y.*, Matsumoto, Y., Tomita, M., Enomoto, A., Morita, A., Sakai, K. Umeda, N., Zhao, H.-J., Nakagawa, K., Ono, T. and Suzuki, N. Phosphorothioate oligonucleotides, suramin and heparin inhibit DNA-dependent protein kinase activity. Brit. J. Cancer, 86, 1143-1149 (2002). PMID: 11953863

43.Komuro, Y.*, Watanabe, T., Hosoi, Y., Matsumoto, Y., Nakagawa, K., Tsuno, N., Kazama, S., Kitayama, J., Suzuki, N. and Nagawa, H. The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma. Cancer 95, 1195-1205 (2002). PMID: 12216085

44.Yoshida, M., Hosoi, Y.*, Miyachi, H., Ishii, N., Matsumoto, Y., Enomoto, A., Nakagawa, K., Yamada, S., Suzuki, N. and Ono, T. Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells. Int. J. Radiat. Biol. 78, 503-512 (2002). PMID: 12065055

45.Mori, N.*, Matsumoto, Y., Okumoto, M.,Suzuki, N. and Yamate, J. Variations in Prkdc encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and susceptibility to radiation-induced apoptosis and lymphomagenesis. Oncogene, 20, 3609-3619 (2001). PMID: 11439324

46.Sakata, K.*, Matsumoto, Y., Satoh, M., Oouchi, A., Nagakura, H., Koito, K., Hosoi, Y., Hareyama, M., and Suzuki, N. Clinical studies of immunohistochemical staining of DNA-dependent protein kinase in oropharyngeal and hypopharyngeal carcinomas. Radiat. Med., 19, 93-97 (2001). PMID: 11383649

47.Sakata, K.*, Matsumoto, Y., Tauchi, H., Satoh, M., Oouchi, A., Nagakura, H., Koito, K., Hosoi, Y., Suzuki, N., Komatsu, K., and Hareyama, M. Expression of genes involved in repair of DNA double-strand breaks in normal and tumor tissues. Int. J. Radiat. Oncol. Biol. Phys., 49, 161-167 (2001). PMID: 11163510

48.Enomoto, A., Suzuki, N.*, Liu, C., Kang, Y., Zhu, J., Serizawa, S., Matsumoto, Y., Morita, A., Ito, M., and Hosoi, Y. Involvement of c-Jun NH2-terminal kinase 1 in heat-induced apoptotic cell death of human monoblastic leukemia U937 cells. Int. J. Radiat. Biol., 867-874 (2001). PMID: 11571020

49.Hosoi, Y.*, Miyachi, H., Matsumoto, Y., Enomoto, A., Nakagawa, K., Suzuki, N. and Ono, T. Induction of interleukin-1beta and interleukin-6 mRNA by low doses of ionizing radiation in macrophages. Int. J. Cancer, 96, 270-276 (2001). PMID: 11582579

50.Matsumoto, Y.*, Suzuki, N., Namba, N., Umeda, N., Ma, X.-J., Morita, A., Tomita, M., Enomoto, A., Serizawa, S., Hirano, K., Sakai, K., Yasuda, H., and Hosoi, Y. Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation. FEBS Lett. 478, 67-71 (2000). PMID: 10922471

51.Tomita, M., Suzuki, N.*, Matsumoto, Y., Hirano, K., Umeda, N., and Sakai, K. Sensitization by wortmannin of heat- or X-ray induced cell death in cultured chinese hamster V79 cells. J. Radiat. Res. 41, 93-102 (2000). PMID: 11037577

52.Enomoto, A., Suzuki, N.*, Hirano, K., Matsumoto, Y., Morita, A., Sakai, K., and Koyama, H. Involvement of SAPK/JNK pathway in X-ray-induced rapid cell death of human T-cell leukemia cell line MOLT-4. Cancer Lett. 155, 137-144 (2000). PMID: 10822128

53.Morita, A., Suzuki, N.*, Matsumoto, Y., Hirano, K., Enomoto, A., Zhu, J., and Sakai, K. p41 as a possible marker for cell death is generated by caspase cleavage of p42/SET in irradiated MOLT-4 cells. Biochem. Biophys. Res. Commun., 278, 627-632 (2000). PMID: 11095960

54.Matsumoto, Y., Umeda, N., Suzuki, N.*, Sakai, K., and Hirano, K. A gel-electrophoretic analysis for improved sensitivity and specificity of DNA-dependent protein kinase activity. J. Radiat. Res. 40, 183-196 (1999). PMID: 10494149

55.Hosoi, Y.*, Miyachi, H., Matsumoto, Y., Ikehata, H., Komura, J., Ishii, K., Zhao, H.-J., Yoshida, M., Takai, Y., Yamada, S., Suzuki, N., and Ono, T. A PI-3 kinase inhibitor, wortmannin, induces radioresistant DNA synthesis, and sensitizes cells to bleomycin and ionizing radiation. Int. J. Cancer 78, 642-647 (1998). PMID: 9808536

56.Matsumoto, Y., Suzuki, N.*, Sakai, K., Morimatsu, A., Hirano, K., and Murofushi H. A possible mechanism for hyperthermic radiosensitization mediated through hyperthermic lability of Ku subunits in DNA-dependent protein kinase. Biochem. Biophys. Res. Commun. 234, 568-572 (1997). PMID: 9175753

57.Morimatsu, A., Suzuki, N.*, Hirano, K., Matsumoto, Y., and Sakai, K. Identification and characterization of a protein found after X-irradiation in human T cell leukemia. J. Radiat. Res. 37, 1-11 (1996). PMID: 8699391


【国際会議プロシーディングス】

1.Wanotayan R, Sharma MK, Matsumoto Y. Function of XRCC4 C-terminal Region in DNA Double-Strand Break Repair. The 2014 American Nuclear Society, Winter Meeting, California, USA. Transactions of the American Nuclear Society, Vol. 111, 1145-1148.


【英文総説等(査読有)】

1. Matsumoto, Y.*, Imamichi, S., Fukuchi, M., Liu, S., Wanotayan, R., Kuniyoshi, S., Yoshida, K., Mae, Y., Sharma, M.K. Radiosensitization strategy through modification of DNA double-strand break repair. In “DNA Repair-New Research Directions”, Edit. Chen, C. ISBN 980-953-307-746-3, InTech pp.639-661 (2013)

2.Kamdar, R.P., Matsumoto, Y*. DNA double-strand break repair through non-homologous end-joining: Recruitment and assembly of the players. “DNA Repair”, Edit. Kruman, I. ISBN: 978-953-307-697-3, InTech, pp. 477-502 (2011)

3.Sakata, K.*, Someya, M., Matsumoto, Y., and Hareyama, M. Ability to repair DNA double-strand breaks related to cancer susceptibility and radiosensitivity. Radiat. Med. 25, 433-438 (2007). PMID: 18026900


【英文総説等(査読無)】

1.Kumar, A.*, Matsumoto, Y.  Radiation protection by herbs and plants.  In “Emerging Trends in Zoology” Edit. Srivastva, U.C. and Kumar, S. Narendra Publishing House (2011).



【和文総説・解説等】

1.松本義久 「二つのDNA二重鎖切断修復機構の賢い選択」 医学物理 34(2), 1-8 (2014). (Matsumoto, Y. Smart Choice between Two DNA Double-strand Break Repair Mechanisms. Japanese Journal of Medical Physics, 34, 1-8 (2014)

2.松本義久 「放射線の人体影響の生物学的基礎」 日本職業・災害医学会会誌 61, 180-185 (2013). (Matsumoto, Y. Biological Basis of Radiation Effects on Human Health. Japanese Journal of Occupational Medicine and Traumatology, 61, 180-185, 2013)

3.松本義久 「放射線生物研究者から見た放射線のリスク」 全漬研漬物技術 25, 44-64 (2012).

4.松本義久 「放射線生物研究者から見た放射線のリスク Risk of Radiation from the Aspect of Radiation Biology」 特集・放射性物質を理解する―基礎、測定・検査法、食品や人体への影響―(「フード・フォラム・つくば」より) 食品と開発 47(1), 15-18 (2011).

5.松本義久 「DNA二重鎖切断に対する生体防御機構と医療応用」 表面科学 32(9), 569-574 (2011).(Matsumoto, Y.Biological Defense Mechanism against DNA Double-Strand Break and Its Possible Medical Application.)【査読有】

6.松本義久 「DNA二重鎖切断の修復とシグナル伝達」 細胞 The CELL 43(6), 4-8 (2011).

7.松本義久Mukesh Kumar SharmaRadhika Pankaj Kamdar 「非相同末端結合の素過程の解明と臨床応用への展望」 癌の臨床 56, 431-435 (2010).

8.坂田耕一、高木克、染谷正則、田内広、松本義久、晴山雅人、福島正和 「ギメラシルによる放射線増感作用」 癌の臨床 56, 441-443 (2010).

9.松本義久 「DNA切断の「認識」の分子生物学―The End is the Beginning」 電気学会OQD-10-002 (2010).

10.松本義久 「Not at the end of DNA double-strand break repair:新たに発見されたDNA二重鎖切断修復の重要分子XLF/Cernunnos」 放射線生物研究 41, 325-331 (2006).

11.松本義久 「DNA二重鎖切断センサー:DNA依存性プロテインキナーゼ(DNA-PK)機能研究の現状と課題」 放射線生物研究 40, 82-108 (2005).

12.松本義久、梅田典子、冨田雅典、細井義夫、鈴木紀夫 「DNA依存性プロテインキナーゼの性質と放射線感受性-DNA-PKの温熱不安定性と温熱の放射線増感効果について-」 癌の臨床 47, 3-7 (2001).

13.松本義久 「イノシトールヘキサキスリン酸がDNA2重鎖切断の修復に関与する!?」 放射線生物研究 38, 70-73 (2001).

14.松本義久 「DNA依存性プロテインキナーゼ(DNA-PK)とその放射線応答における意義-The end is the beginning of the story.-」 放射線生物研究 31, 1-27 (1996).

15.鈴木紀夫, 酒井一夫, 松本義久. 「癌細胞とApoptosis」 癌と化学療法 20(8), 997-1005 (1993).


【報告等】

1.松本義久 「DNA切断センサーDNA-PKの性質と機能に関する研究−その成果は癌診断・治療にいかに生かせるか?」 癌と人 33, 31-32 (2006).

2.松本義久 「第1回アジア若手放射線生物学研究者会合開催記」 放射線生物研究 40, 461-465 (2005).


【著書等】

1. 松本義久 「放射線によるDNA損傷の修復」 大西武雄監修「放射線医科学」, 18-21, 学会出版センター(2007).

2. 松本義久 「放射線によるDNA損傷・修復と細胞死」 日本放射線腫瘍学会・日本放射線腫瘍学研究機構編「臨床放射線腫瘍学」, 40-44, 南江堂(2012).


【工業所有権】

1. 坂田耕一、染谷正則、松本義久 「癌の診断方法、及び癌の罹病性の判定方法」 出願人:北海道ティー・エル・オー株式会社、出願番号:PCTF157、出願日:2003年6月4日

2. 松本義久ムケッシュ クマール シャルマ今道祥二福地命、冨田雅典 「DNA依存性プロテインキナーゼ活性の測定方法、被検細胞の放射線感受性の判定方法、被検細胞の癌罹患性の判定方法、DNA依存性プロテインキナーゼの阻害剤又は活性化剤のスクリーニング方法、及びキット」、出願番号:特願2014-134624、出願日:2014年6月30日


【招待講演・特別講演等】

1.松本義久. DNA二重鎖切断の認識・修復の分子機構からがん診断・治療へ. 第33回法政大学イオンビーム工学研究所シンポジウム, 法政大学(東京・小金井), 2014年12月10日, 招待講演Ⅰ.

2.松本義久. 放射線生物学研究者から見た福島第一原発事故. 第27回イオン交換セミナー, 上智大学(東京), 2014年7月4日, 講演1

3.Matsumoto, Y. Fukushima Daiichi Nuclear Power Plant Accident from the Aspect of Radiation Biologist. International Conference of Radiation Biology 2012, Navi Mumbai (Advanced Centre for Treatment, Research and Education of Cancer), India, 22-24 November 2012, Inaugural Session (Invited Talk).

4.Matsumoto, Y. Fukushima Daiichi Nuclear Power Plant Accident from the Aspect of Radiation Biologist. International Conference on Radiation, Cancer and Society, Allahabad (Auditorium, Vigyan, Parisad), India, 26-28 November 2012, Symposium Talk (Invited).

5.Matsumoto, Y. Fukushima Daiichi Nuclear Power Plant Accident from the Aspect of Radiation Biologist II Countermeasures and Social Responsibilities.  International Conference on Radiation, Cancer and Society, Allahabad (Auditorium, Vigyan, Parisad), India, 26-28 November 2012, Symposium Talk (Invited).

6.サマー・サイエンスキャンプ2012/サイエンスキャンプDX/第33回数理の翼夏期セミナー 「DNA損傷に対する生体防御機構の分子・細胞生物学」 2012年8月10日、川崎市青少年の家(川崎市)

7.松本 義久. 放射線影響の分子生物学 (Radiation Effects from the Aspect of Molecular Biology). 第24回DV-Xα研究会, 静岡(静岡大学), 2011年8月8日〜10日

8.Matsumoto, Y., Sharma, M.K., Kamdar, R.P. and Sharma, A.  Missing Links in the DNA Double-Strand Break Repair Mechanism and Its Possible Application to Cancer Therapy. International Conference on Radiation Biology: Nanotechnology, Imaging and Stem Cell Research in Radiation Oncology, Chennai (Sri Ramachandra University), India, 15-17 November 2010, Symposium Talk (Invited) S14-IL-86

9. 細胞生物学会ランチョンセミナー(日本ミリポア主催) 「The End Is the Beginning-DNA二重鎖切断認識•修復研究の現状と展望」 2010年5月19日、大阪国際会議場(大阪市).

10. Lecture at University of Rajasthan, Department of Zoology “DNA-dependent Protein Kinase: The Sensor of DNA double-strand Break and Critical Determinant of Radiosensitivity” 25 November 2006, University of Rajasthan (Jaipur, India).

11. International Conference on Radiation Biology "Missing link in the mechanism of DNA double-strand break repair through non-homologouse end-joining pathway" 20 November 2006, Banaras Hindu University (Varanasi, India).

12. ACTREC Lecture "DNA-PK: The Sensor of DNA Double-Strand Breaks Bringing Us Many Hopes in Cancer Therapy and Diagnosis" 17 November 2006, The Advanced Centre for Training Education & Research in Cancer, The Tata Memorial Centre (Mumbai, India).

13. 東北大学加齢医学研究所研究員会セミナー 「DNA切断センサーDNA-PKの性質と機能:新しいサイエンス・フロンティアとがん診断・治療への応用の可能性」 2006年2月22日、東北大学(仙台市).

14. 広島大学21世紀COEプログラム第13回セミナー 「DNA切断センサーDNA-PKの性質と機能:新しいサイエンス・フロンティアとがん診断・治療への応用の可能性」 2005年9月1日、広島大学(広島市).

理研セミナー 「DNA切断センサーDNA-PKの性質と機能:新しいサイエンス・フロンティアとがん診断・治療への応用の可能性」 2005年1月7日、理化学研究所

 

受賞等

松本 義久

1. 平成19年度東京工業大学挑戦的研究賞「DNA二重鎖切断の認識・修復の分子機構解明とがん放射線治療への応用」

  1. 2.平成17年度日本放射線影響学会奨励賞「DNA二重鎖切断センサー:DNA-PKの性質と機能に関する研究」

  2. 3.平成23年若手表彰原子力基礎基盤戦略研究イニシアティブ若手原子力プログラム「DNA二重鎖切断の認識・修復の初期過程に関する研究」

4.平成24年度科研費審査委員表彰 独立行政法人日本学術振興会

5.平成26年度日本放射線腫瘍学会生物部会賞


Mukesh Kumar Sharma

  1. 1.9回(2008年)国際癌治療増感研究協会国際研究奨励賞


Radhika Pankaj Kamdar

1. 2nd Asian Congress of Radiation Research (May 2009 Seoul), Best Poster Award


今道 祥二

1. 2nd Asian Congress of Radiation Research (May 2009 Seoul), Best Poster Award


福地 命

  1. 1.平成21年度 創造エネルギー専攻優秀論文発表賞


木村 小督

  1. 1.平成22年度9月修了 原子核工学優秀論文発表賞


吉田 和起

1. 平成24年度 原子核工学専攻優秀論文発表賞

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